ISSN 1662-4009 (online)

ey0016.11-15 | Treatment of Severe Obesity: Next Steps | ESPEYB16

11.15. Working toward precision medicine approaches to treat severe obesity in adolescents: report of an NIH workshop

AS Kelly , MD Marcus , JA Yanovski , SZ Yanovski , SK Osganian

To read the full abstract: Int J Obes (2005) 2018; 42(11):1834–1844This paper presents the results of a multidisciplinary expert workshop to identify current knowledge and more importantly current gaps in knowledge on the epidemiological and biopsychosocial determinants of obesity and its optimal treatment approaches.Childhood obesity is a global ...

ey0020.8-9 | New Paradigms | ESPEYB20

8.9. Elevations in blood glucose before and after the appearance of islet autoantibodies in children

K Warncke , A Weiss , P Achenbach , T von dem Berge , R Berner , K Casteels , L Groele , K Hatzikotoulas , A Hommel , O Kordonouri , H Elding Larsson , M Lundgren , BA Marcus , MD Snape , A Szypowska , JA Todd , E Bonifacio , AG Ziegler , GPPAD POInT Study Groups

Brief summary: In this longitudinal study, blood glucose trajectories and their relationship with autoantibodies appearance were assessed in 1050 children with high genetic risk of type 1 diabetes (T1D) between 4 months and 3.6 years. Post-prandial blood glucose levels increased around 2 months prior to autoantibody seroconversion, with further increases thereafter, suggesting that islet autoimmunity co-occurs or follows insults on the β-cells.This ...